ea0011p519 | Endocrine tumours and neoplasia | ECE2006
Stigliano AS
, Cerquetti LC
, Bucci BB
, Carlini PC
, Amendola DA
, Misiti SM
, Miceli RM
, de Paula UDP
, Brunetti EB
, Toscano VT
Background: Mitotane,(o,p-DDD)is a compound with potent adrenotoxic effect and is able to block cortisol synthesis by inhibiting 11β-hydroxylation and cholesterol chain cleavage. For these reasons, mitotane was widely used in the treatment of adrenocortical cancer. Nevertheless the biological mechanism induced by these treatments in this cancer cells remain unknown.Aim: To study whether the o,p-DDD could increase the susceptibility to th...